A case of spinal muscular atrophy type 0 treated with nusinersen without progression of early-onset scoliosis – possibility of preventing scoliosis with a rehabilitation program focusing on postural management
Our case suggests that early proactive, non-surgical management with targeted rehabilitation can prevent scoliosis progression in SMA patients with 2 copies of SMN2 that receive post-onset DMT within 6 months of birth.
Authors
- Keiko Yanagihara (ORCID: https://orcid.org/0000-0003-2708-4550)
- Yukiko Mogami (ORCID: https://orcid.org/0000-0002-1599-0276)
- Takuya Horibe
- Tomokazu Kimizu (ORCID: https://orcid.org/0000-0003-2809-4670)
- Daisuke Tamura (ORCID: https://orcid.org/0000-0001-9808-1897)
- Ken Nakajima (ORCID: https://orcid.org/0000-0002-3722-744X)
- Koji Tominaga
- Keisuke Oki
- Saki Yokawa
Institutions
- Osaka Women's and Children's Hospital (JP)
Publication Details
- Journal
- Brain and Development
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.braindev.2025.104354
- Citations
- 5
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- Japan Agency for Medical Research and Development