Detecting <scp>PI3K</scp> and <scp>TP53</scp> Pathway Disruptions in Early‐Onset Colorectal Cancer Among Hispanic/Latino Patients
These findings highlight the distinct role of PI3K and TP53 pathway disruptions in early-onset CRC among Hispanic/Latino patients, suggesting that pathway-specific mechanisms may drive cancer health disparities. Insights from this study could inform the potential development of precision medicine approaches and targeted therapies aimed at addressing these disparities.
Authors
- Francisco Carranza (ORCID: https://orcid.org/0000-0003-1789-4197)
- Enrique Velazquez‐Villarreal (ORCID: https://orcid.org/0000-0002-3603-6414)
- Cecilia Monge (ORCID: https://orcid.org/0000-0002-5558-2744)
- Sophia Manjarrez (ORCID: https://orcid.org/0009-0006-0607-1784)
- Brigette Waldrup (ORCID: https://orcid.org/0009-0009-5991-9779)
Institutions
- City of Hope (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Beckman Research Institute
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/cam4.70791
- Citations
- 18
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 26.49
Funders
- Comprehensive Cancer Center, City of Hope
- National Institutes of Health
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot