VDAC2 Loss Induces Inflammation and Immune-Mediated Tumor Cell Killing

Major Finding: VDAC2 blocks IFNγ-mediated tumor cell killing and anticancer inflammatory immune reprogramming. Concept: Mitochondrial DNA release and subsequent STING activation mediate VDAC2 loss–induced antitumor inflammatory phenotypes. Impact: VDAC2 is a promising therapeutic target that may enhance the anticancer efficacy of immunotherapies.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-036
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

VDAC2 Loss Induces Inflammation and Immune-Mediated Tumor Cell Killing

Cancer Discovery
RNA Interference and Gene Delivery
article

VDAC2 Loss Induces Inflammation and Immune-Mediated Tumor Cell Killing

article en

Abstract

Major Finding: VDAC2 blocks IFNγ-mediated tumor cell killing and anticancer inflammatory immune reprogramming. Concept: Mitochondrial DNA release and subsequent STING activation mediate VDAC2 loss–induced antitumor inflammatory phenotypes. Impact: VDAC2 is a promising therapeutic target that may enhance the anticancer efficacy of immunotherapies.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 94%
RNA Interference and Gene Delivery
DOISourceOpenAlex
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VDAC2 Loss Induces Inflammation and Immune-Mediated Tumor Cell Killing · Cancer Discovery (2025) | TGRS Research Map | TGRS