LOX-1 rewires glutamine ammonia metabolism to drive liver fibrosis
Our findings uncover the pivotal role of LOX-1 in the progression of liver fibrosis, enrich the pathological significance of LOX-1 regulation of hepatic ammonia metabolism, and provide an insight into promising targets for the therapeutic strategy of liver fibrosis, demonstrating the potential clinical value of targeting LOX-1 in antifibrotic therapy.
Authors
- Chang‐Ping Hu (ORCID: https://orcid.org/0000-0002-7138-4801)
- Chuankui Fu (ORCID: https://orcid.org/0000-0001-7446-7410)
- Ruihua Huang (ORCID: https://orcid.org/0000-0002-4722-2271)
- Shuhan Zhou (ORCID: https://orcid.org/0000-0002-7131-5144)
- Xiaoyun Zhu
- Mingyuan Cai (ORCID: https://orcid.org/0009-0001-6802-9745)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-3206-4856)
- H. Cui (ORCID: https://orcid.org/0000-0002-9923-1313)
- Mohammed Abdulaziz Yahya Ali Alshami
Institutions
- Central South University (CN)
- Yantai University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.molmet.2025.102132
- Citations
- 1
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.39