Prevention of insulin-induced lipohypertrophy by coadministration of a low dose of high-affinity PI3K inhibitors
We now show evidence indicating that ILH is caused by pathological PI3K activation at insulin injection sites and that ILH can be prevented by local inhibition of PI3K activity at the injection site.
Authors
- Andrea Usseglio Gaudi (ORCID: https://orcid.org/0000-0003-1723-6880)
- Giovanni Solinas (ORCID: https://orcid.org/0000-0002-0140-2621)
- Barbara Becattini (ORCID: https://orcid.org/0000-0002-1002-6891)
- Per‐Anders Jansson (ORCID: https://orcid.org/0000-0003-4032-3317)
Institutions
- Peter MacCallum Cancer Centre (AU)
- Wallenberg Wood Science Center (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Metabolism
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.metabol.2025.156252
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Novo Nordisk Fonden