Iron-Catalyzed Site-Selective Bromination of Benzylic C(sp<sup>3</sup>)–H Bonds
An iron-catalyzed chemo- and site-selective benzylic C-H bromination has been described. The practical approach uses the C-H substrate as the limiting reagent and commercially available iron(II) bromide at a loading of 1 mol % as the catalyst without the involvement of any extrinsic ligand. The simple and mild reaction can be readily scaled up to gram quantity with good functional group tolerance, offering a convenient route for the late-stage diversification of complex bioactive natural products and pharmaceutical molecules through sequential benzylic C-H bromination.
Authors
- Meijuan Zhou (ORCID: https://orcid.org/0000-0002-4332-8351)
- Min Cao (ORCID: https://orcid.org/0000-0002-7726-4050)
- Yongyong Ji
- Xiaolong Yu (ORCID: https://orcid.org/0000-0003-1720-5806)
- Shengying Li (ORCID: https://orcid.org/0000-0002-5244-870X)
- Zihao Xu (ORCID: https://orcid.org/0000-0003-0805-8533)
- Lei Liu (ORCID: https://orcid.org/0000-0002-0839-373X)
- Guangyi Zhang (ORCID: https://orcid.org/0000-0003-0994-211X)
- Bing Han (ORCID: https://orcid.org/0000-0003-0507-9742)
Institutions
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Shandong First Medical University (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.5c00864
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Shandong University
- National Natural Science Foundation of China
- Taishan Scholar Project of Shandong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Natural Science Fund for Distinguished Young Scholars of Shandong Province
- National Key Research and Development Program of China