The Spatial Location of Chromosomes in Dividing Cells and the Relative Stability of Chromosome Spatial Structure
The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions. We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior. In this study, we explored the relative spatial positional relationships of chromosomes [t(9;22) and t(15;17)] in B-ALL cells by using the three-dimensional DNA fluorescent in situ hybridization (3D-FISH) method. The results showed that chromosomes [t(9;22) and t(15;17)] showed relatively stable spatial relationships. The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease.
Authors
- Suning Chen (ORCID: https://orcid.org/0000-0001-6294-972X)
- Jinlan Pan (ORCID: https://orcid.org/0000-0002-8042-537X)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-2429-3229)
- Di Jiang (ORCID: https://orcid.org/0000-0003-1676-4868)
- Lei Xu (ORCID: https://orcid.org/0000-0002-7055-7774)
- Zhigang Guo
- Meng Zhao (ORCID: https://orcid.org/0009-0007-4710-3954)
- Qin Zhu (ORCID: https://orcid.org/0000-0002-2407-7796)
- Chunxiao Wu
- Qian Xu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Normal University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Southeast University (CN)
Publication Details
- Journal
- Proceedings of Anticancer Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.26689/par.v9i2.9965
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00