Epidemiological Analysis of 9,064 Cases of Non- Hodgkin Lymphoma

Objective: This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma (NHL) in China through a retrospective analysis of 9,064 NHL cases. Methods: Clinical data of 9,064 patients were collected from 555 hospitals in 28 provinces of China. Results: Among 9,064 NHL patients, there were 5,241 males (57.8%) and 3,823 females (42.2%), with a male-to-female ratio of 1.37:1. Patients aged ≥ 45 years old accounted for 89.6%, with a mean age of 61.87 ± 13.30 years. The predominant NHL subtypes were diffuse large B-cell lymphoma (DLBCL, 45.2%), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL, 19.8%), marginal zone lymphoma (MZL, 13.9%), mantle cell lymphoma (MCL, 9.7%), and central nervous system lymphoma (CNSL, 4.3%). Combination therapy served as the primary treatment modality across all NHL subtypes. Conclusions: NHL in China demonstrates male predominance and primarily affects middle-aged and elderly populations, with combination chemotherapy remaining the mainstay therapeutic approach.