Native group-directed double Heck arylation of internal alkenes <i>via</i> selective β-H elimination
A Pd-catalyzed, ligand-free method for β,δ-selective consecutive arylation of internal alkenes with aryl iodides has been developed. This transformation employs a native group-directed double Heck arylation, utilizing selective β-H elimination to achieve precise regiochemical control. The protocol demonstrates high efficiency and broad functional group tolerance.
Authors
- Yu Du (ORCID: https://orcid.org/0000-0003-2287-5265)
- Weiping Su (ORCID: https://orcid.org/0000-0001-5695-6333)
- Runze Luan
- Tianming Liu (ORCID: https://orcid.org/0000-0002-8132-9048)
- Siqing Liu (ORCID: https://orcid.org/0000-0002-7235-1075)
- Jiali Wang
Institutions
- Fujian Normal University (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00821b
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94