Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with ALS due to SOD1 Mutation. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.
Authors
- Xinbo Ji
- Xiaohan Sun
- Hongxu Wang (ORCID: https://orcid.org/0000-0001-5248-4578)
- Bo Kong
- Ping Sun (ORCID: https://orcid.org/0000-0002-1466-863X)
- Bo Gao (ORCID: https://orcid.org/0000-0002-4029-1258)
- Haoran Mu (ORCID: https://orcid.org/0000-0003-4763-1363)
- Bo Li (ORCID: https://orcid.org/0000-0003-0668-1620)
- Jianing Li (ORCID: https://orcid.org/0000-0002-8999-9310)
- Yu Wang (ORCID: https://orcid.org/0000-0001-6962-7897)
- Yingxin Wang (ORCID: https://orcid.org/0000-0001-9032-9990)
- Fuchen Liu
- Yitong Yang (ORCID: https://orcid.org/0009-0007-2601-2420)
- Yao Tang
- Didi Shan
- Zexin Zhan
- Yichang Jiao (ORCID: https://orcid.org/0009-0004-2703-1912)
Institutions
- Qilu Hospital of Shandong University (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.scr.2025.103704
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00