Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway
Our study demonstrated in vitro experiments that baicalin attenuates IL-1β-stimulated IVDD by inhibiting activation of the P38 MAPK signaling pathway. Meanwhile, the effects of baicalin were also confirmed in vivo experiments, Consequently, we propose that baicalin is a promising therapeutic agent for the treatment of disc degeneration.
Authors
- Yating Wu (ORCID: https://orcid.org/0000-0001-9280-7669)
- Fengrui Li
- Sen Li (ORCID: https://orcid.org/0009-0009-5716-8617)
- Yong Qiu (ORCID: https://orcid.org/0000-0002-2444-4744)
- Zezhang Zhu (ORCID: https://orcid.org/0000-0003-4617-2994)
- Zhen‐Hua Feng
- Shibin Shu
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.exger.2025.112743
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94