Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models
Low LDL-C levels (<70 mg/dL (<1.8 mmol/L)) are significantly associated with a reduced risk of dementia, including ADRD, with statin therapy providing additional protective effects. These findings support the necessity of targeted lipid management as a preventive strategy against dementia, indicating the importance of personalised treatment approaches.
Authors
- Sang Youl Rhee (ORCID: https://orcid.org/0000-0003-0119-5818)
- Seunguk Jung
- Ju-Hun Lee (ORCID: https://orcid.org/0000-0001-6831-7248)
- Jong Seok Bae (ORCID: https://orcid.org/0000-0002-4313-1786)
- Kyung Joo Lee (ORCID: https://orcid.org/0000-0002-5965-8064)
- Jinseob Kim (ORCID: https://orcid.org/0000-0002-9403-605X)
- Yerim Kim (ORCID: https://orcid.org/0000-0002-7108-6302)
- Jeeun Lee (ORCID: https://orcid.org/0000-0002-2359-7116)
- Hyeon‐Jong Yang (ORCID: https://orcid.org/0000-0002-7287-4300)
- Jae‐Won Jang (ORCID: https://orcid.org/0000-0003-3540-530X)
- Rae Woong Park (ORCID: https://orcid.org/0000-0003-4989-3287)
- Jae Myung (ORCID: https://orcid.org/0000-0001-9403-230X)
- Dong Yun Lee (ORCID: https://orcid.org/0000-0002-3678-9862)
- Chulho Kim (ORCID: https://orcid.org/0000-0001-8762-8340)
- Minwoo Lee (ORCID: https://orcid.org/0000-0001-8474-5744)
- Sang‐Hwa Lee (ORCID: https://orcid.org/0000-0002-0609-1551)
- Yeo Jin Kim
- Hyoeun Bae
Institutions
- Hallym University (KR)
- Kangwon National University (KR)
- Changwon National University (KR)
- Korea Forest Service (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Kyung Hee University (KR)
- Sacred Heart Hospital (NG)
- Sacred Heart Hospital (US)
- Korea Pharma (South Korea) (KR)
- Kangwon National University Hospital (KR)
- Myongji Hospital (KR)
- Sacred Heart Hospital (US)
- Kangdong Sacred Heart Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Hallym University Sacred Heart Hospital (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
- Ajou University (KR)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jnnp-2024-334708
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Korean Neurological Association