Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus
There is a need for additional data regarding the influence of fractionation and multiple beam planning. The results of this study can be used to develop roadmaps to guide future clinical trial design.
Authors
- Jeffrey D. Bradley (ORCID: https://orcid.org/0000-0003-3047-3151)
- Liyong Lin (ORCID: https://orcid.org/0000-0002-0820-8063)
- Marie‐Catherine Vozenin (ORCID: https://orcid.org/0000-0002-2109-8073)
- Mischa S. Hoogeman (ORCID: https://orcid.org/0000-0002-4264-9903)
- Sibo Tian (ORCID: https://orcid.org/0000-0001-5018-4854)
- Cai Grau (ORCID: https://orcid.org/0000-0003-3548-3527)
- Matthew J. Ferris (ORCID: https://orcid.org/0000-0003-0402-4707)
- P.R. Poulsen (ORCID: https://orcid.org/0000-0001-9940-7609)
- Chandan Guha (ORCID: https://orcid.org/0000-0002-1906-2186)
- Maria Hawkins
- S. Zhou (ORCID: https://orcid.org/0000-0002-7517-9653)
- Anthony Mascia (ORCID: https://orcid.org/0000-0002-4819-3062)
- Christopher D. Willey (ORCID: https://orcid.org/0000-0001-9953-0279)
- Charles B. Simone (ORCID: https://orcid.org/0000-0002-0867-3694)
- Lewis Z. Shi (ORCID: https://orcid.org/0000-0002-5351-8730)
- Haibo Lin
- Q. Richard Lu (ORCID: https://orcid.org/0000-0001-6846-9014)
- J. Isabelle Choi (ORCID: https://orcid.org/0000-0003-0897-6668)
- Yvonne L.B. Klaver
- Richard A. Amos
- Brita Singers Sørensen
- Astrid Moerman
Institutions
- University of Maryland, Baltimore (US)
- Cincinnati Children's Hospital Medical Center (US)
- Nebraska Medical Center (US)
- University of Maryland Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- University College London Hospitals NHS Foundation Trust (GB)
- Emory University (US)
- Leiden University Medical Center (NL)
- Aarhus University Hospital (DK)
- University of Alabama at Birmingham (US)
- University Hospital of Geneva (CH)
- Montefiore Hospital (GB)
- Erasmus MC Cancer Institute (NL)
- University College London (GB)
- University of Nebraska Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.03.047
- Citations
- 5
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- AstraZeneca
- Focused Ultrasound Foundation
- Emory University
- Varian Medical Systems
- Aarhus Universitet
- Oral and Maxillofacial Surgery Foundation
- Celldex Therapeutics
- CERN
- Novocure
- Accuray
- Cancer Research UK
- Associazione Italiana per la Ricerca sul Cancro
- Siemens Healthineers
- Swiss Cancer Research Foundation
- National Institutes of Health
- Genentech
- EMD Serono
- Winship Cancer Institute
- Janssen Pharmaceuticals