Study on the synthesis and biological activity of trifluoroacetamide promoted by base without transition metal participation

We report a coupling reaction without transition metal catalysis, introducing the efficient synthesis of trifluoroacetylaniline compounds using dibromotrifluoroacetone as the trifluoroacetylation reagent. The reaction conditions are mild, requiring only an equivalent amount of base to achieve this reaction. The substrate has good tolerance for functional groups and a wide range of substrates. More importantly, we studied the biological bactericidal activity of two compounds and found that com-pound 3z has a good bactericidal effect, with a bactericidal rate of over 99% against Bacillus subtilis. We firmly believe that this research result will provide a good technical foundation for later drug molecular screening.