Quantum Dot Interface-Enabled Cross-Coupling Acylation by Direct Aldehyde Activation under Visible Light
Cross-coupling acylation by direct aldehyde activation is ideal to construct a useful carbonyl motif. However, the strong C-H bond energy, short radical lifetime, and mismatched radical polarity render this reaction a huge challenge. Herein, the semiconductor quantum dots (QDs) interface is demonstrated to overcome the obstacles lying on the way to acylating alkene or alkylarene, directly activating the formyl C-H bond into an acyl radical. Further stabilization of the obtained radical species by the QD interface ensured their effective cross-coupling with the generated intermediate from the coupling partner. The interface of QDs was exemplified to execute photochemical transformation, showcasing a highly efficient and selective cross-coupling acylation reaction under extremely mild conditions.
Authors
- Xiao-Jun He
- Xiaoning Guo (ORCID: https://orcid.org/0000-0001-7626-1539)
- Chen‐Ho Tung (ORCID: https://orcid.org/0000-0001-9999-9755)
- Li‐Zhu Wu (ORCID: https://orcid.org/0000-0002-5561-9922)
- Bin Chen (ORCID: https://orcid.org/0000-0003-0437-1442)
- Lijun Zhang (ORCID: https://orcid.org/0000-0002-3692-2088)
- Chao Zhou (ORCID: https://orcid.org/0000-0003-4942-8422)
- Zan Liu (ORCID: https://orcid.org/0000-0003-2447-4270)
- Yang Wang (ORCID: https://orcid.org/0000-0002-5048-1514)
Institutions
- Chinese Academy of Sciences (CN)
- Technical Institute of Physics and Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1021/acsnano.5c01858
- Citations
- 4
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Shandong Province
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China