Inflammatory and neutrophil extracellular trap markers to predict cardiac events after ST-segment elevation myocardial infarction
Circulating levels of the NET marker H3Cit-DNA at the time of primary PCI were not predictive of cardiovascular events following STEMI. In contrast, the classical inflammatory markers CRP and interleukin-6 significantly enhanced the discriminative capacity of a clinical 30-day risk prediction model. These findings suggest that measuring circulating NET-specific markers may have limited utility in assessing the inflammatory state during the early stages of STEMI.
Authors
- Elvira Ramil (ORCID: https://orcid.org/0000-0003-0785-3826)
- Charlotte Thålin (ORCID: https://orcid.org/0000-0002-1345-6491)
- María José Coronado (ORCID: https://orcid.org/0000-0003-0281-3366)
- Axel Rosell (ORCID: https://orcid.org/0000-0001-6280-0562)
- Raquel Castejón (ORCID: https://orcid.org/0000-0002-9765-0303)
- Ana Royuela (ORCID: https://orcid.org/0000-0003-1665-081X)
- Juan Manuel Escudier-Villa (ORCID: https://orcid.org/0000-0003-3603-8433)
- A Blasco (ORCID: https://orcid.org/0000-0001-9067-6773)
- Paloma Martín (ORCID: https://orcid.org/0000-0002-3274-4595)
- Silvia Elorza
- Julio Vázquez (ORCID: https://orcid.org/0000-0001-9692-2015)
- Carmen Bellas
- Javier Ortega
- Carolina González-Andrés
Institutions
- Karolinska Institutet (SE)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1371/journal.pone.0319759
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Sociedad Española de Cardiología
- Instituto de Salud Carlos III