Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function
Voluntary wheel running can improve the mitochondrial function of renal cells and reduce oxidative stress damage, thus playing a protective role against nephrotoxicity caused by DOX. This study provides a new way to reduce the adverse reactions to chemotherapy in combination with the application of chemical drugs.
Authors
- Xin Jiang (ORCID: https://orcid.org/0000-0002-4613-7438)
- Longyun Wang
- Lijing Zhao (ORCID: https://orcid.org/0000-0002-3190-7399)
- Zeyu Wang (ORCID: https://orcid.org/0000-0002-1223-1661)
- Yuqi Wang (ORCID: https://orcid.org/0000-0002-9793-6002)
- Hongyu Jiang (ORCID: https://orcid.org/0000-0003-0218-845X)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1371/journal.pone.0321121
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00