Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Our findings demonstrate that tumour cell-derived ligand expression and extracellular matrix remodelling sustain Wnt signalling during DGC progression. These complementary mechanisms promote niche independence enabling expansion of undifferentiated DGC cells needed for the development of advanced tumours.
Authors
- Lars J S Kemp (ORCID: https://orcid.org/0000-0002-9898-7469)
- Marjolein J. Vliem
- Jolanda M. van Dieren (ORCID: https://orcid.org/0000-0003-3958-4990)
- Rachel S. van der Post
- Lodewijk A.A. Brosens (ORCID: https://orcid.org/0000-0003-1341-8994)
- Tanya M. Bisseling (ORCID: https://orcid.org/0000-0001-7976-7949)
- Colin S. Wood (ORCID: https://orcid.org/0000-0001-7005-6171)
- Antoine Khalil (ORCID: https://orcid.org/0000-0003-3469-0778)
- Liudmila L. Kodach (ORCID: https://orcid.org/0000-0003-2487-3204)
- Nigel B. Jamieson (ORCID: https://orcid.org/0000-0002-9552-4725)
- Martijn Gloerich (ORCID: https://orcid.org/0000-0002-0034-4642)
- Jooske L. Monster (ORCID: https://orcid.org/0000-0002-9966-5402)
- Martijn Moers
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- University of Glasgow (GB)
Publication Details
- Journal
- Gut
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/gutjnl-2024-334589
- Citations
- 5
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- ZonMw
- KWF Kankerbestrijding
- Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek