Clinical significance of anti-Ro and Anti-La antibodies: The role of isolated anti-La
ObjectivesThe aim of the present study was to describe demographic, clinical, and immunological characteristics of SLE patients with anti-La/SSB antibodies positive versus anti-La/SSB negative patients.MethodsRetrospective cross-sectional study, including all patients with SLE (≥4 ACR-1997 criteria) recruited in RELESSER registry. Sociodemographic, clinical, serological and comorbidities variables were collected. Anti-Ro-/La + patients were compared with the rest of the patients.ResultsIn a study involving 4219 systemic lupus erythematosus (SLE) patients, 44/3893 (1.1%) were found to be positive for isolated anti-La/SSB antibodies. The mean age was 33.77 years, with a majority being female (88.6%) and Caucasian (90.5%). The most frequent comorbidities were smoking (48.8%), dyslipidemia (47.7%), and arterial hypertension (31.8%). Photosensitivity and mucosal ulcers were more common in anti-Ro+/La + patients compared to anti-Ro+/La- and anti-Ro-/La- patients. Anti-Ro+/La + patients had a lower frequency of lupus nephritis compared to anti-Ro+/La- patients. A multivariable regression model, considering various confounding factors, was applied to compare anti-La/SSB positive patients with negative ones. Isolated anti-La/SSB positive patients showed a lower occurrence of lupus nephritis and a higher frequency of cardiac manifestations.ConclusionsThe study suggests that patients with isolated anti-La/SSB antibodies may have a unique clinical profile, with a potential protective effect against lupus nephritis but an increased likelihood of cardiac manifestations.
Authors
- Mónica Ibáñez Barceló (ORCID: https://orcid.org/0000-0002-6439-8965)
- Javier Narváez (ORCID: https://orcid.org/0000-0002-1614-8064)
- E. Tomero Muriel (ORCID: https://orcid.org/0000-0002-0871-4038)
- Eva Salgado-Pérez
- Íñigo Rúa‐Figueroa (ORCID: https://orcid.org/0000-0002-7894-1690)
- O. Ibarguengoitia
- Carlos Montilla (ORCID: https://orcid.org/0000-0003-2258-2868)
- Rocío Caño (ORCID: https://orcid.org/0000-0002-2803-4347)
- Ángela Pecondón
- Clara Sangüesa Gómez (ORCID: https://orcid.org/0000-0003-4638-1278)
- Julia Martínez‐Barrio (ORCID: https://orcid.org/0000-0002-9670-1746)
- María Jesús García-Villanueva (ORCID: https://orcid.org/0000-0002-0441-6623)
- Víctor Quevedo Vila
- Antonio Fernández‐Nebro (ORCID: https://orcid.org/0000-0002-2962-9844)
- Loreto Horcada
- José María Pego‐Reigosa (ORCID: https://orcid.org/0000-0003-3461-3537)
- Jaime Calvo‐Alén (ORCID: https://orcid.org/0000-0001-9378-8412)
- María Galindo-Izquierdo (ORCID: https://orcid.org/0000-0002-7264-2577)
- Nuria Lozano‐Rivas
- Paloma Vela (ORCID: https://orcid.org/0000-0001-8566-5172)
- Tomás Ramón Vázquez Rodríguez
- José Luís Andreu (ORCID: https://orcid.org/0000-0002-6002-1239)
- Tarek Carlos Salman-Monte (ORCID: https://orcid.org/0000-0002-4676-0174)
- Lorena Expósito (ORCID: https://orcid.org/0000-0002-5386-3091)
- Beatriz Romero (ORCID: https://orcid.org/0000-0002-3424-6901)
- Mercedes Freire González (ORCID: https://orcid.org/0000-0001-9242-8925)
- Víctor M. Martínez-Taboada
- Virginia Moreira
- Gema Bonilla Hernán
- Elena Aurrecoechea Aguinaga
- Irene Altabás González
- Alejandro Olivé
- Gregorio Santos Soler
- Javier Nóvoa
- Vicente Torrente-Segarra
- E. Uriarte Isacelaya
- Raúl Menor Almagro
- A. Pérez Gómez
- Clara Moriano Morales
- Joan Calvet Fontonova
Institutions
- Universidade da Coruña (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Hospital Universitario de Canarias (ES)
- Hospital Universitario La Paz (ES)
- Bellvitge University Hospital (ES)
- University Hospital Complex Of Vigo (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Son Llatzer (ES)
- Hospital Universitario Virgen Macarena (ES)
- Hospital de Basurto (ES)
- Complejo Hospitalario de Navarra (ES)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Hospital Leforte (BR)
- Complejo Hospitalario de Salamanca (ES)
- Marqués de Valdecilla University Hospital (ES)
- Biogipuzkoa Health Research Institute (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Sierrallana (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Hospital Regional Universitario de Málaga (ES)
- Hospital Universitario Araba (ES)
- Hospital Universitario Miguel Servet (ES)
- Corporació Sanitària Parc Taulí (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Del Mar (ES)
- Hospital de Sant Joan Despí Moisès Broggi (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitario Lucus Augusti (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Fundación Canaria de Investigación Sanitaria (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Jerez Puerta del Sur (ES)
- Hospital Marina Baixa (ES)
- Hospital Universitario Severo Ochoa (ES)
- Hospital Universitario de León (ES)
- Hospital Universitario Infanta Sofía (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Complejo Hospitalario de Ourense (ES)
Publication Details
- Journal
- Lupus
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1177/09612033251331249
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00