Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles

A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. <i>N</i>-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.