Organometallic Reagent-Free Iron-Catalyzed C–Cl Bond Activation of Aryl Chlorines
The formation of C-C and C-S bonds is fundamentally important for the production of pharmaceuticals, biologically active molecules, and organic natural products. Herein, we report an unprecedented iron-catalyzed process for C-C and C-S bond coupling to achieve the 1,2-arylthiolation of alkenes. This process proceeds efficiently without the use of organometallic reagents and features readily available starting materials, a broad substrate scope, and simple reaction conditions.
Authors
- Dayong Shi (ORCID: https://orcid.org/0000-0001-8941-5285)
- Leifeng Yuan (ORCID: https://orcid.org/0009-0005-5082-3712)
- Cong Shi (ORCID: https://orcid.org/0009-0000-5681-3834)
- Xiangqian Li (ORCID: https://orcid.org/0000-0002-5807-5633)
- Zemin Wang
- Xiaowei Li (ORCID: https://orcid.org/0000-0001-7586-2850)
- Wenli Zhuang
Institutions
- Shandong University (CN)
- Qingdao Binhai University (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.5c00877
- Citations
- 2
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Department of Science and Technology of Shandong Province
- Natural Science Foundation of Shandong Province
- Key Technology Research and Development Program of Shandong
- National Key Research and Development Program of China