Nickel-Catalyzed 1,1-Carboboration of Polysubstituted Internal Alkenes
Herein, we report a nickel-catalyzed 1,1-carboboration of di- and trisubstituted alkenyl boronates through a chain-walking strategy. This reaction effectively addresses the polarity-mismatch problem via ligand control, enabling the coupling of various carbon-based electrophiles while accommodating a broad range of functional groups. The approach yields diverse tetrasubstituted carbon <i>gem</i>-diboronate derivatives with exceptional regioselectivity. The synthetic utility of this method is further demonstrated through the concise synthesis of high-value bioactive molecules.
Authors
- Guoyin Yin (ORCID: https://orcid.org/0000-0002-2179-4634)
- Yu Liu (ORCID: https://orcid.org/0000-0003-1304-9498)
- Shiyang Wang (ORCID: https://orcid.org/0000-0003-2442-2788)
- Yao Tong (ORCID: https://orcid.org/0000-0003-3718-0394)
- Yangyang Li (ORCID: https://orcid.org/0000-0001-7052-8909)
Institutions
- Wuhan University (CN)
- Advanced Institute of Materials Science (JP)
- Changchun University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.5c00654
- Citations
- 3
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Fundamental Research Funds for the Central Universities