Garciyndiphenyls A and B, Two Biphenyl Dimers with a Caged Skeleton from <i>Garcinia yunnanensis</i>

Two pairs of enantiomers of biphenyl dimers, garciyndiphenyls A and B [(±)-<b>1</b> and (±)-<b>2</b>], were isolated from <i>Garcinia yunnanensis</i>. These compounds represent the first example of a complex polycyclic caged skeleton of biphenyl dimers. Their structures and absolute configurations were determined through comprehensive spectroscopic analysis, X-ray crystallography, and electronic circular dichroism (ECD) calculations. Additionally, plausible biosynthetic routes for compounds <b>1</b> and <b>2</b> were proposed. Both compounds exhibited potential antimigration and anti-invasion effects in human lung cancer cells.