T-bet+CD11c+ age-associated B cells resist BLyS- and CD20-targeted ablation in murine lupus models
The spleen-resident T-bet<sup>+</sup>CD11c<sup>+</sup> ABC pool resists anti-BLyS and anti-CD20 ablative treatment. These findings have implications for antibody-mediated ablative strategies in patients with autoimmune diseases.
Authors
- James J. Knox (ORCID: https://orcid.org/0000-0002-3523-0661)
- Jean L. Scholz (ORCID: https://orcid.org/0000-0002-7414-4248)
- Michael P. Cancro (ORCID: https://orcid.org/0000-0002-8659-3227)
- Hannah Futeran
- Sofia Cataliotti
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.jaut.2025.103410
- Citations
- 3
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- GlaxoSmithKline