Dynamics of T cell subpopulations and plasma cytokines during the first year of antineoplastic therapy in patients with breast cancer: the BEGYN-1 study
We conclude that in breast cancer patients, chemotherapy is associated with a transition from a Th1 immune response towards Th2 and an increase in cytotoxic T cells, whereas in patients without chemotherapy, these alterations were less pronounced. Future studies should clarify whether patterns of T cell subsets or plasma cytokines can be used as biomarkers to monitor or even improve therapeutic interventions.
Authors
- Carolin Müller (ORCID: https://orcid.org/0000-0003-3488-5073)
- Cosima Zemlin (ORCID: https://orcid.org/0000-0001-6629-9912)
- Gudrun Wagenpfeil (ORCID: https://orcid.org/0000-0002-1133-2049)
- Regine Weber (ORCID: https://orcid.org/0000-0001-7620-2432)
- Erich‐Franz Solomayer (ORCID: https://orcid.org/0000-0002-2622-5676)
- Sybelle Goedicke‐Fritz (ORCID: https://orcid.org/0000-0003-1005-4873)
- Elisabeth Kaiser (ORCID: https://orcid.org/0000-0002-1771-8479)
- Michelle Bous (ORCID: https://orcid.org/0009-0000-2607-1577)
- Muriel Charlotte Hans
- Michael Zemlin (ORCID: https://orcid.org/0000-0001-9528-7419)
- Melanie Hirschstein
- Hala Mazid
- Emilie Marie Suzanne Kapps
Institutions
- Cleveland Clinic (US)
- Outcomes Research Consortium (US)
- Comprehensive Cancer Center Erlangen (DE)
- Saarland University (DE)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s13058-025-01997-9
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Universität des Saarlandes