Human Source Severe Acute Respiratory Syndrome Coronavirus 2 Aerosol Transmission to Remote Sentinel Hamsters
These results support the concept that viral bioaerosols generated from patients remain infectious over long-distance transport through a building ventilation system. The seroconversion among sentinel animals supports the long-held belief that airborne infections manifest as a stochastic rather than deterministic event that is subject to a threshold dose effect. Further confirmatory studies are necessary to characterize the relationship between the bioaerosol delivered and the infections that result in this controlled H2A transmission model.
Authors
- Michael R. Barer (ORCID: https://orcid.org/0000-0002-0377-3100)
- Dahlia Cordier
- Elsabe De Kock
- Richard L. Vincent (ORCID: https://orcid.org/0000-0003-3453-4070)
- Brandon J. Beddingfield (ORCID: https://orcid.org/0000-0002-9438-1304)
- Edward A. Nardell (ORCID: https://orcid.org/0000-0002-5323-3196)
- Paul Jensen (ORCID: https://orcid.org/0000-0001-7367-4952)
- Veronica Ueckermann (ORCID: https://orcid.org/0000-0002-4419-3583)
- Chad J. Roy (ORCID: https://orcid.org/0000-0002-1710-6974)
- P. Bernard Fourie (ORCID: https://orcid.org/0000-0002-1630-3554)
- Oliva De Kock
- Sego Dibobo
- Toby VanReenen
Institutions
- Tulane University (US)
- University of Leicester (GB)
- Fins Medical University (UG)
- Harvard Global Health Institute (US)
- NIHR Leicester Biomedical Research Centre (GB)
- University of Pretoria (ZA)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1093/ofid/ofaf196
- Citations
- 1
- Primary Topic
- Infection Control and Ventilation
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Ushio
- National Institutes of Health
- NIHR Leicester Biomedical Research Centre