A video summary of the TOPAZ-1 Study PLSP: Durvalumab and Chemotherapy for Advanced Biliary Tract Cancer

The phase III study, TOPAZ-1, compared treatment with durvalumab and chemotherapy with treatment with placebo and chemotherapy in advanced biliary tract cancer (BTC). Participants who took durvalumab and chemotherapy were more likely to live longer than participants who took placebo and chemotherapy. Side effects were similar across treatment groups. Overall, these results support durvalumab and chemotherapy as a new treatment option for people with advanced BTC.

Authors

Publication Details

Journal
Video Journal of Biomedicine
Published
2025-04-01
DOI
https://doi.org/10.1080/vjbm-2023-0017
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

A video summary of the TOPAZ-1 Study PLSP: Durvalumab and Chemotherapy for Advanced Biliary Tract Cancer

Do‐Youn Oh
2 links
Video Journal of Biomedicine
Cholangiocarcinoma and Gallbladder Cancer Studies
article

A video summary of the TOPAZ-1 Study PLSP: Durvalumab and Chemotherapy for Advanced Biliary Tract Cancer

Do‐Youn Oh
article en

Abstract

The phase III study, TOPAZ-1, compared treatment with durvalumab and chemotherapy with treatment with placebo and chemotherapy in advanced biliary tract cancer (BTC). Participants who took durvalumab and chemotherapy were more likely to live longer than participants who took placebo and chemotherapy. Side effects were similar across treatment groups. Overall, these results support durvalumab and chemotherapy as a new treatment option for people with advanced BTC.

Video Journal of Biomedicine
Openalex Percentile: Top 89%
Cholangiocarcinoma and Gallbladder Cancer Studies
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A video summary of the TOPAZ-1 Study PLSP: Durvalumab and Chemotherapy for Advanced Biliary Tract Cancer — Do‐Youn Oh · Video Journal of Biomedicine (2025) | TGRS Research Map | TGRS