Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication

Foot-and-mouth disease (FMD) severely restricts the healthy development of global animal husbandry, and the unclear pathogenic mechanism of FMD virus (FMDV) leads to difficulty in preventing and purifying FMD. Glycolytic remodelling is considered one of the hallmarks of viral infection, providing energy and precursors for viral assembly and replication. In this work, the interaction and mechanism between FMDV and glycolysis were explored from the perspective of immune metabolism. We found that FMDV infection increased the extracellular acidification rate, lactic acid accumulation, and HK2 level. In addition, during FMDV infection, HK2 enhances glycolytic activity and mediates autophagic degradation of IRF3/7 to antagonize the innate immune response, thereby promoting viral replication. Our findings provide evidence that FMDV is closely correlated with host metabolism, increasing the understanding that glycolysis and HK2 facilitate virus infection, and provide new ideas for further elucidating the pathogenic mechanism of FMDV.

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Publication Details

Journal
Veterinary Research
Published
2025-04-01
DOI
https://doi.org/10.1186/s13567-025-01497-w
Citations
5
Primary Topic
Animal Disease Management and Epidemiology
Type
article
Field-Weighted Citation Impact
9.51

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article

Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication

Bingke Li, Zhaoyao Li, Jinding Chen, Yaoyao Huang et al.
5 citations
Veterinary Research
Animal Disease Management and Epidemiology
9.51
article

Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication

Bingke Li, Zhaoyao Li, Jinding Chen, Yaoyao Huang, Hongxing Ding, Keke Wu, Yufeng He, Yuwei Qin, Pengfei Liu, Xinyan Wang, Weijun Wang, Xiaowen Li, Yi Lin, Mingqiu Zhao, Wenxian Chen, Shuangqi Fan, Sen Zeng, Lianxiang Wang
article en
5 citations

Abstract

Foot-and-mouth disease (FMD) severely restricts the healthy development of global animal husbandry, and the unclear pathogenic mechanism of FMD virus (FMDV) leads to difficulty in preventing and purifying FMD. Glycolytic remodelling is considered one of the hallmarks of viral infection, providing energy and precursors for viral assembly and replication. In this work, the interaction and mechanism between FMDV and glycolysis were explored from the perspective of immune metabolism. We found that FMDV infection increased the extracellular acidification rate, lactic acid accumulation, and HK2 level. In addition, during FMDV infection, HK2 enhances glycolytic activity and mediates autophagic degradation of IRF3/7 to antagonize the innate immune response, thereby promoting viral replication. Our findings provide evidence that FMDV is closely correlated with host metabolism, increasing the understanding that glycolysis and HK2 facilitate virus infection, and provide new ideas for further elucidating the pathogenic mechanism of FMDV.

Veterinary ResearchVol. 56(1)
South China Agricultural University (CN), Lanzhou Veterinary Research Institute (CN), Wen's Food Group (China) (CN)
Gansu Postdoctoral Science Foundation, China Agricultural University, South China Agricultural University, Guangzhou Science and Technology Innovation Center
Openalex Percentile: Top 2%
Animal Disease Management and Epidemiology
9.51
DOIOpen Access PDFOpenAlex
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