Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome
Variants in the candidate genes LPA and APOE are associated with an increased risk of acute coronary syndrome in a population from northeastern Colombia. The effects of rs6511720 in LDLR and rs2227631 in SERPINE1 differ according to smoking habits and are significant in non-smokers. These results are helpful for early risk screening of acute coronary syndrome, mainly in individuals without defined conventional risk factors.
Authors
- Liliana Franco (ORCID: https://orcid.org/0000-0001-9430-2808)
- Clara Saldarriaga (ORCID: https://orcid.org/0000-0002-5945-1127)
- Jenny García Valencia (ORCID: https://orcid.org/0000-0002-9998-5318)
- Evert Armando Jiménez-Cotes (ORCID: https://orcid.org/0000-0001-9325-6977)
- Cristian Arbey Velarde (ORCID: https://orcid.org/0000-0002-5350-1832)
- Ana Valencia (ORCID: https://orcid.org/0000-0001-9133-218X)
- Juan Carlos Arango Viana (ORCID: https://orcid.org/0000-0003-0017-402X)
- Nathalia González-Jaramillo (ORCID: https://orcid.org/0000-0003-4975-4439)
- S.M. Pinto De Carvalho (ORCID: https://orcid.org/0000-0001-6905-9527)
- Luisa María Parra-Rodas (ORCID: https://orcid.org/0000-0002-0345-8776)
- Paola Parra (ORCID: https://orcid.org/0000-0002-0822-619X)
- Juan Pablo Pérez Bedoya (ORCID: https://orcid.org/0000-0002-2474-6603)
- Kelly Betancur-Salazar (ORCID: https://orcid.org/0000-0002-0226-470X)
- Natalia Gallego
- Diana Valencia (ORCID: https://orcid.org/0000-0002-9020-3965)
- Cecilia Martínez (ORCID: https://orcid.org/0000-0003-3748-2368)
- Kelly Marisancen
Institutions
- Universidad Pontificia Bolivariana (CO)
- Universidad de Antioquia (CO)
- Clínica CES (CO)
Publication Details
- Journal
- Biomédica
- Published
- 2025-03-28
- DOI
- https://doi.org/10.7705/biomedica.7379
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Universidad de Antioquia
- Universidad Pontificia Bolivariana