Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine <i>Okeania</i> sp. Cyanobacterium
Sealgamide (<b>1</b>), a new antitrypanosomal lipopeptide, was isolated from a marine <i>Okeania</i> sp. cyanobacterium. Elucidation of its structure was challenging due to signal overlap caused by conspicuous rotamers but was ultimately achieved through partial hydrolysis and subsequent spectroscopic analyses. Sealgamide (<b>1</b>) exhibited moderate antitrypanosomal activity against <i>Trypanosoma brucei rhodesiense</i> (IC<sub>50</sub> 2.9 μM) while showing no antimalarial activity (IC<sub>50</sub> > 25 μM) or cytotoxicity (IC<sub>50</sub> > 30 μM). Furthermore, we discovered that an artificial C-terminal methyl ester analogue (<b>2</b>) exhibited notably enhanced antiparasitic activity.
Authors
- Kiyotake Suenaga (ORCID: https://orcid.org/0000-0001-5343-5890)
- Ghulam Jeelani (ORCID: https://orcid.org/0000-0003-0816-9831)
- Tomoyoshi Nozaki (ORCID: https://orcid.org/0000-0003-1354-5133)
- Naoaki Kurisawa (ORCID: https://orcid.org/0000-0002-3204-7693)
- Adnan Luthfi Agusta
- Kairi Umeda
- Kazuki Wakai
Institutions
- Keio University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00141
- Citations
- 1
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Keio University
- Japan Society for the Promotion of Science