Distinct circulating monocyte profiles in chronic cannabis users compared to cocaine users without changes in plasma levels of proinflammatory cytokines and LPS
Chronic use of cannabis, but not cocaine, is associated with shifts in non-activated monocyte subset distribution, characterized by increased classical and decreased non-classical monocyte subsets, without concurrent systemic cytokine dysregulation or LPS translocation. These findings highlight substance-specific immune effects, potentially affecting long-term immune function.
Authors
- Sylvia Fitting (ORCID: https://orcid.org/0000-0002-8906-3133)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-1374-053X)
- Douglas Johnson (ORCID: https://orcid.org/0009-0009-5148-4061)
- Zizhang Sheng (ORCID: https://orcid.org/0000-0002-3253-3309)
- Zhenwu Luo
Institutions
- University of North Carolina at Chapel Hill (US)
- Medical University of South Carolina (US)
- Aaron Diamond AIDS Research Center (US)
- Ralph H. Johnson VA Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- NeuroImmune Pharmacology and Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1515/nipt-2025-0003
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse