Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis
We identified 53 potential ubiquitination related genes of IPF through bioinformatics analysis. CDC20 and ITCH and other ubiquitination related genes may influence the development of IPF through epithelial mesenchymal transition and inflammatory response. Our research findings provide insights into the mechanisms of fibrosis and may provide evidence for potential therapeutic targets for fibrosis.
Authors
- Jing Feng (ORCID: https://orcid.org/0000-0003-3719-9319)
- Yubao Wang (ORCID: https://orcid.org/0000-0003-0332-7984)
- Shulei Sun
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s41065-025-00401-y
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China