Exploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, pathogenic bacteria, and serum metabolomic profiles between NF-PitNET patients and healthy controls. The gut microbiome was assessed through 16S rRNA sequencing, while serum metabolomics was analyzed using mass spectrometry. Correlation analyses identified potential links between microbial characteristics and metabolic markers. The results revealed that specific pathogenic bacteria, such as Bacteroides, were significantly enriched in NF-PitNET patients. Multi-omics correlations suggested that altered microbiota might contribute to NF-PitNET pathogenesis by modulating host metabolic pathways. These findings highlight the potential role of gut microbiome dysbiosis and its metabolic effects in NF-PitNET development, offering insights into possible therapeutic and diagnostic targets.

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Publication Details

Journal
Frontiers in Microbiology
Published
2025-04-01
DOI
https://doi.org/10.3389/fmicb.2025.1541683
Citations
2
Primary Topic
Pituitary Gland Disorders and Treatments
Type
article
Field-Weighted Citation Impact
2.59
Controls
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article

Exploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors

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2 citations
Frontiers in Microbiology
Pituitary Gland Disorders and Treatments
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article

Exploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors

Yuchen Wei, Jifang Liu, Qing Zhong, Huijuan Zhu, Hui Pan, Yanan Shi, Renzhi Wang, Kan Deng, Yi Zhang, Lulu Liu, Pei Wang, Lin Lü, Jiao Lü, Xiaomin Hu, Tianqi Chen, Yong Yao, Zhenhua Cai, Jun Pu, Jinghua Liu, Wan Su, Zhang Ye, Jie Liu
article en
2 citations

Abstract

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, pathogenic bacteria, and serum metabolomic profiles between NF-PitNET patients and healthy controls. The gut microbiome was assessed through 16S rRNA sequencing, while serum metabolomics was analyzed using mass spectrometry. Correlation analyses identified potential links between microbial characteristics and metabolic markers. The results revealed that specific pathogenic bacteria, such as Bacteroides, were significantly enriched in NF-PitNET patients. Multi-omics correlations suggested that altered microbiota might contribute to NF-PitNET pathogenesis by modulating host metabolic pathways. These findings highlight the potential role of gut microbiome dysbiosis and its metabolic effects in NF-PitNET development, offering insights into possible therapeutic and diagnostic targets.

Frontiers in MicrobiologyVol. 16
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN), Chinese University of Hong Kong, Shenzhen (CN)
Good health and well-being
Openalex Percentile: Top 11%
Pituitary Gland Disorders and Treatments
2.59
DOIOpen Access PDFOpenAlex
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