Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment
Brain region- and age-specific regulation of CB1R in astrocytes critically links THC and unique adolescent amygdala vulnerability to inflammatory gliosis, impairing behaviors implicated in neuropsychiatric disorders. Mitigation of specific THC-induced changes by CBD offers leads for attenuating some adverse effects of THC.
Authors
- Marie-Eve Di Raddo (ORCID: https://orcid.org/0000-0002-7547-5217)
- Myriam Heiman (ORCID: https://orcid.org/0000-0002-6365-8673)
- Bertha K. Madras (ORCID: https://orcid.org/0000-0001-5971-2238)
- Marija Milenković (ORCID: https://orcid.org/0000-0002-3275-2288)
- Meenalochani Sivasubramanian
- Andrew B. Gumbert
- Susan R. George
- Preston Ge (ORCID: https://orcid.org/0000-0001-7933-0843)
- Sarah L. Withey (ORCID: https://orcid.org/0000-0001-9885-8176)
- Ya‐Lin Sun (ORCID: https://orcid.org/0000-0001-6182-7798)
- Jack Bergman
Institutions
- Harvard University (US)
- McGovern Institute for Brain Research (US)
- University of Toronto (CA)
- McLean Hospital (US)
- Institute of Cognitive and Brain Sciences (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100496
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- National Institute on Drug Abuse