De novo donor-specific HLA antibody development after kidney transplantation is impacted by PIRCHE II score and recipient age
Locus-specific PIRCHE II scores are useful in predicting dnDSA risk post-transplantation, particularly in younger recipients. Promoting transplants with low PIRCHE II scores against key HLA loci like HLA-DQ in younger recipients could improve outcomes.
Authors
- Thomas Schachtner (ORCID: https://orcid.org/0000-0001-5549-4798)
- Yuan Tian (ORCID: https://orcid.org/0000-0001-5732-7045)
- Lukas Frischknecht (ORCID: https://orcid.org/0000-0001-5666-5747)
- Jakob Nilsson (ORCID: https://orcid.org/0000-0001-5091-8133)
- Fabian Rössler (ORCID: https://orcid.org/0000-0002-2968-347X)
Institutions
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1508586
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Eurostars