Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF
Our study provides evidence that cardiac lymphatic disruption, driven by impaired BCAA catabolism in LECs, is a key factor contributing to HFpEF. These findings unravel the crucial role of BCAA catabolism in modulating lymphatic biology, and suggest that preserving cardiac lymphatic integrity may present a novel therapeutic strategy for HFpEF.
Authors
- Ling Zhang (ORCID: https://orcid.org/0000-0001-8850-9706)
- Fangfang Sun (ORCID: https://orcid.org/0000-0002-5507-749X)
- Ling Tao (ORCID: https://orcid.org/0000-0003-2919-5641)
- Chong Huang (ORCID: https://orcid.org/0000-0001-7057-9992)
- Yongzhen Guo (ORCID: https://orcid.org/0000-0001-5686-8114)
- Zhengyang Wang (ORCID: https://orcid.org/0009-0000-3225-5954)
- Congye Li (ORCID: https://orcid.org/0000-0001-9443-1642)
- Tongzheng Li (ORCID: https://orcid.org/0000-0002-7067-1358)
- Yunhui Du (ORCID: https://orcid.org/0000-0002-6077-6826)
- Xiyao Chen (ORCID: https://orcid.org/0009-0003-7315-2427)
- Fuyang Zhang (ORCID: https://orcid.org/0000-0002-6335-9809)
- Zhiyuan Liu (ORCID: https://orcid.org/0000-0001-9738-2719)
- Guangyu Hu (ORCID: https://orcid.org/0000-0002-9091-4484)
- Wenjun Yan (ORCID: https://orcid.org/0000-0003-3568-4265)
- Xiong Guo (ORCID: https://orcid.org/0000-0003-4413-5022)
- Hui Liu (ORCID: https://orcid.org/0009-0008-7644-208X)
- Zhe Cui (ORCID: https://orcid.org/0000-0002-1993-2137)
- Xinyi Wang (ORCID: https://orcid.org/0000-0001-9511-7209)
- Shan Wang (ORCID: https://orcid.org/0000-0002-9487-0829)
- Yunlong Xia (ORCID: https://orcid.org/0000-0001-7985-3273)
- Zhen Lin (ORCID: https://orcid.org/0009-0007-4574-6235)
Institutions
- Beijing Anzhen Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1161/circulationaha.124.071741
- Citations
- 11
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 11.50