A comparative analysis of lesional skin, sentinel flap, and mucosal biopsies in assessing acute face transplant rejection
Mucosal biopsies tend to capture the full spectrum of rejection, whereas skin biopsies alone may miss important rejection events occurring in the mucosa. Mucosal biopsies should be integrated into routine monitoring alongside skin biopsies, as they not only sensitively function as sentinel tissue but also provide critical insights into rejection activity that may otherwise go undetected. This dual approach could improve overall transplant surveillance. Inconsistencies in rejection patterns between the two tissues highlight the need for a reworked grading system.
Authors
- Bohdan Pomahač (ORCID: https://orcid.org/0000-0003-3703-8240)
- Rachael A. Clark (ORCID: https://orcid.org/0000-0002-6105-5764)
- Gëorge F. Murphy (ORCID: https://orcid.org/0000-0001-9362-5146)
- Stav Brown
- Federico Repetto (ORCID: https://orcid.org/0009-0007-2792-3955)
- Christine J. Ko (ORCID: https://orcid.org/0000-0003-2270-2524)
- Fortunay Diatta (ORCID: https://orcid.org/0000-0001-9138-5871)
- Lioba Huelsboemer (ORCID: https://orcid.org/0000-0003-4795-0225)
- Samuel A. Knoedler (ORCID: https://orcid.org/0000-0001-5798-8003)
- Christine G. Lian (ORCID: https://orcid.org/0000-0003-4626-1612)
- Felix J Klimitz (ORCID: https://orcid.org/0000-0002-1278-0505)
- William J. Crisler (ORCID: https://orcid.org/0000-0003-1767-9809)
- Martin Kauke-Navarro
- Leonard Knoedler (ORCID: https://orcid.org/0009-0009-4279-5669)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Yale University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1562024
- Citations
- 5
- Primary Topic
- Organ and Tissue Transplantation Research
- Type
- article
- Field-Weighted Citation Impact
- 9.93