The dual role of TIGIT in regulatory and effector T cells in chronic liver disease
We identified a highly suppressive subset of regulatory T cells in the liver, defined as TIGIT<sup>+</sup>CD39<sup>+</sup>CTLA-4<sup>+</sup>Tregs. TIGIT agonists and IL-2 enhanced the suppressive function of this cell subset. The TIGIT ligand, CD155, is expressed on inflamed hepatocytes, and TIGIT blockade in oncology could instigate checkpoint inhibitor induced liver injury (CHILI). These findings have implications for future therapy in liver disease.
Authors
- Scott Davies (ORCID: https://orcid.org/0000-0001-6899-1339)
- Ye Htun Oo (ORCID: https://orcid.org/0000-0002-0495-6734)
- Amber Bozward (ORCID: https://orcid.org/0000-0001-6637-8952)
- Sian Faustini (ORCID: https://orcid.org/0000-0002-9300-5569)
- Sean Michael Morris (ORCID: https://orcid.org/0000-0001-6025-6399)
- Rémi Fiancette (ORCID: https://orcid.org/0000-0003-1531-9770)
- Gary Middleton (ORCID: https://orcid.org/0000-0001-5695-3474)
- Grace Wootton (ORCID: https://orcid.org/0009-0005-7641-8053)
- Naomi Richardson (ORCID: https://orcid.org/0000-0001-9682-9857)
- Kayani Kayani (ORCID: https://orcid.org/0000-0002-8122-3139)
- Hin Kwok
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- University College Birmingham (GB)
- ERN GUARD-Heart (NL)
- Genomics (United Kingdom) (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101405
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Queen Elizabeth Hospital Birmingham Charity
- Sir Jules Thorn Charitable Trust
- Royal College of Physicians
- Birmingham Biomedical Research Centre