Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD
The underlying mechanisms of maternal obesity contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) severity in the offspring are not completely understood. Our study characterises the impact of multigenerational maternal Western diet on offspring MASLD development and identifies mitochondrial dysfunction as a contributor to disease severity. In this setting, pharmacological compounds targeting mitochondrial dysfunction appear to have the greatest therapeutic potential.
Authors
- Sander Lefere (ORCID: https://orcid.org/0000-0001-5734-3467)
- Anja M. Geerts (ORCID: https://orcid.org/0000-0002-2218-9081)
- Xavier Verhelst (ORCID: https://orcid.org/0000-0002-2798-5415)
- Anneleen Heldens
- Louis Onghena (ORCID: https://orcid.org/0000-0002-8516-4834)
- Lindsey Devisscher (ORCID: https://orcid.org/0000-0003-4862-9580)
- Hans Van Vlierberghe (ORCID: https://orcid.org/0000-0003-0647-9238)
- Arnaud Vanlander (ORCID: https://orcid.org/0000-0002-9520-5564)
- Ruth De Bruyne (ORCID: https://orcid.org/0000-0002-5623-3300)
- Tim Meese (ORCID: https://orcid.org/0000-0002-3307-9048)
- Joél Smet (ORCID: https://orcid.org/0000-0002-9551-6282)
- Sarah Raevens (ORCID: https://orcid.org/0000-0003-2810-7507)
- Milton Antwi (ORCID: https://orcid.org/0000-0001-8831-073X)
- Yannick Gansemans (ORCID: https://orcid.org/0000-0001-5018-044X)
- Filip Van Nieuwerburgh (ORCID: https://orcid.org/0000-0001-8815-5485)
- Ellen Dupont (ORCID: https://orcid.org/0009-0000-5723-4199)
Institutions
- Ghent University Hospital (BE)
- Ghent University (BE)
- VIB-UGent Center for Medical Biotechnology (BE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101404
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Fonds Wetenschappelijk Onderzoek
- Universitair Ziekenhuis Gent
- Universiteit Gent
- Vlaamse regering