Quantum LLM Model for Entity and Semantic Relation Extraction in Drug Interactions

In modern natural language processing, it is still difficult to extract entity and semantic links from biomedical literature, such as drug-drug, drug-gene, drug-test, drug-disease, drug-herb, drug-food and drug-lab range interactions. In this work XLNet, a large language model based on transformers, is finetuned with Bayesian network that have been improved by the Quantum Approximate Optimization Algorithm (QAOA) by using directed acyclic graphs (DAGs) and Conditional Probability Tables (CPTs) to model complicated biomedical interactions. This work combines the ability of XLNet to capture two-way context with the ability of Bayesian networks to use probabilistic reasoning. QAOA improves computing performance by allowing scalable inference on big datasets. Ranked on a benchmark biomedical dataset, our strategy exceeded current techniques with a 94% accuracy in relationship extraction. With consistency, practical data from unstructured texts, this development improves the accuracy and interpretability of scientific findings, hence enabling drug discovery and personalized treatment.

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Publication Details

Journal
Advances in Artificial Intelligence and Machine Learning
Published
2025-01-01
DOI
https://doi.org/10.54364/aaiml.2025.51200
Primary Topic
Topic Modeling
Type
article
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article

Quantum LLM Model for Entity and Semantic Relation Extraction in Drug Interactions

Anush Sankaran, K. Sathiyamurthy
Advances in Artificial Intelligence and Machine Learning
Topic Modeling
article

Quantum LLM Model for Entity and Semantic Relation Extraction in Drug Interactions

Anush Sankaran, K. Sathiyamurthy
article en

Abstract

In modern natural language processing, it is still difficult to extract entity and semantic links from biomedical literature, such as drug-drug, drug-gene, drug-test, drug-disease, drug-herb, drug-food and drug-lab range interactions. In this work XLNet, a large language model based on transformers, is finetuned with Bayesian network that have been improved by the Quantum Approximate Optimization Algorithm (QAOA) by using directed acyclic graphs (DAGs) and Conditional Probability Tables (CPTs) to model complicated biomedical interactions. This work combines the ability of XLNet to capture two-way context with the ability of Bayesian networks to use probabilistic reasoning. QAOA improves computing performance by allowing scalable inference on big datasets. Ranked on a benchmark biomedical dataset, our strategy exceeded current techniques with a 94% accuracy in relationship extraction. With consistency, practical data from unstructured texts, this development improves the accuracy and interpretability of scientific findings, hence enabling drug discovery and personalized treatment.

Advances in Artificial Intelligence and Machine LearningVol. 05(01)
Openalex Percentile: Top 97%
Topic Modeling
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Quantum LLM Model for Entity and Semantic Relation Extraction in Drug Interactions — Anush Sankaran, K. Sathiyamurthy · Advances in Artificial Intelligence and Machine Learning (2025) | TGRS Research Map | TGRS