Kynurenic Acid and Promotion of Activity-Dependent Synapse Elimination in Schizophrenia
Together, these results link genetic risk variants for schizophrenia to elevated production of KYNA and excessive and activity-dependent internalization of synaptic material in microglia, while implicating pharmacological inhibition of KATs as a strategy to avoid synapse loss in schizophrenia.
Authors
- Marja Koskuvi (ORCID: https://orcid.org/0000-0002-1646-9992)
- Samudyata Samudyata (ORCID: https://orcid.org/0000-0002-1062-2626)
- Funda Orhan (ORCID: https://orcid.org/0000-0001-7077-2397)
- Kent Jardemark
- Oscar Jungholm (ORCID: https://orcid.org/0000-0003-0992-6101)
- Sophie Erhardt (ORCID: https://orcid.org/0000-0001-7359-5250)
- Lilly Schwieler
- Angelika Langeder
- Göran Engberg (ORCID: https://orcid.org/0000-0003-1659-5232)
- Carl M. Sellgren (ORCID: https://orcid.org/0000-0001-9103-2785)
- Jari Koıstınaho (ORCID: https://orcid.org/0000-0001-6559-1153)
- Jari Tiihonen (ORCID: https://orcid.org/0000-0002-0400-6798)
- Neda Khanlarkhani (ORCID: https://orcid.org/0000-0002-8438-0623)
- Šárka Lehtonen (ORCID: https://orcid.org/0000-0002-5055-9414)
- Susmita Malwade (ORCID: https://orcid.org/0000-0002-6756-018X)
- Asimenia Gkogka (ORCID: https://orcid.org/0009-0001-7892-0769)
Institutions
- Karolinska Institutet (SE)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1176/appi.ajp.20240048
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89