Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients

The granzyme-mediated programmed cell death signaling pathway is related to pathogenesis of SCH, and CD244 may serve as potential biological markers for diagnosing SCH. The correlation between enhancement of the DMN and genetic abnormalities was the strongest, followed by the enhancement of the frontal and parietal attention networks. In contrast, the correlation between weakening of the sensory-motor network and occipital network and genetic abnormalities was relatively weak. Additionally, the strongest correlation was observed between MRI features and the KLRD1 and CD244 genes. The use of the 3D DANet method has improved the detection precision of brain structural and functional changes in SCH patients, providing a new perspective for understanding the biological basis of the disease.