Preparation and Characterization of Mitochondrial-Targeted Nitronyl Nitroxide Loaded PLGA Nanoparticles for Brain Injury Induced by Hypobaric Hypoxia in Mice
TPP-C<sub>6</sub>-HPN@PLGA-NPs exhibits good stability, low hemolysis rate, sustained release, low toxicity, and long residence time in brain tissue and can be used as a promising formulation for the proper treatment of HH-induced brain damage.
Authors
- Qingyue Da (ORCID: https://orcid.org/0000-0003-2257-4884)
- Yiting Tian (ORCID: https://orcid.org/0000-0003-0784-8103)
- Huiping Ma (ORCID: https://orcid.org/0000-0003-4560-2155)
- Min Xu (ORCID: https://orcid.org/0000-0002-6936-7543)
- Linlin Jing (ORCID: https://orcid.org/0000-0002-9234-8850)
- Haibo Wang (ORCID: https://orcid.org/0000-0002-0238-3506)
Institutions
- 82th Hospital of Pla (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Central Hospital of Wuhan (CN)
- General Hospital of Central Theater Command
- Air Force Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s507315
- Citations
- 1
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 1.82