A Progesterone Microneedle Patch for Self-Administration in the Prevention of Preterm Birth in a Mouse Model
Microneedle patches loaded with progesterone microemulsion were successfully developed, efficiently delivering progesterone and reversing RU486-induced preterm birth in mice. The MN patch was user-friendly, minimally harmful to skin tissue, safe, and non-toxic, representing a promising new approach for the clinical treatment of premature labor.
Authors
- Zhongwen Yuan (ORCID: https://orcid.org/0000-0002-5082-7909)
- Pengke Yan (ORCID: https://orcid.org/0000-0002-8356-2986)
- Hanhui Huang (ORCID: https://orcid.org/0000-0001-9147-9747)
- Senling Feng (ORCID: https://orcid.org/0000-0001-8326-2046)
- Wenting Zhu (ORCID: https://orcid.org/0000-0001-8910-0523)
- Hang Yu (ORCID: https://orcid.org/0000-0001-6652-5465)
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s502701
- Citations
- 1
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.79