Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I
In diabetic animals, enhanced binding of Sp1 to the FECH promoter may be responsible for the increase in FECH mRNA levels. However, this increase was not reflected in the amount of FECH protein, which would confirm that FECH could be another control point in heme synthesis.
Authors
- Esther Noemí Gerez (ORCID: https://orcid.org/0000-0001-6393-5805)
- Ana Marı́a Buzaleh
- Leda Oliveri
Institutions
- Universidad de Buenos Aires (AR)
- Pontificia Universidad Católica Argentina (AR)
- Hospital de Clínicas "José de San Martín" (AR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.bbrep.2025.101989
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00