Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue
This head-to-head study provides evidence that while [<sup>18</sup>F]AZD4694 and [<sup>11</sup>C]PiB bindings are highly correlated with both tracers competing for the same binding sites, [<sup>18</sup>F]AZD4694 has a slightly higher effect size when comparing between neuropathologically-confirmed AD and HC brain tissues.
Authors
- Serge Gauthier (ORCID: https://orcid.org/0000-0003-4272-3330)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Aline Rigon Zimmer (ORCID: https://orcid.org/0000-0002-8309-7068)
- Arturo Aliaga
- Luiza Santos Machado (ORCID: https://orcid.org/0000-0001-8387-3832)
- Jesse Klostranec (ORCID: https://orcid.org/0000-0003-3553-0530)
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Giovanna Carello‐Collar (ORCID: https://orcid.org/0000-0003-4644-0151)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Peter Kunach (ORCID: https://orcid.org/0000-0001-7428-6812)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Aida Mary Abreu Diaz (ORCID: https://orcid.org/0000-0002-6301-3496)
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Kely Quispialaya (ORCID: https://orcid.org/0009-0000-6982-7143)
- Andréia Silva da Rocha (ORCID: https://orcid.org/0000-0003-1567-3374)
- Jean-Paul R. Soucy (ORCID: https://orcid.org/0000-0002-8422-2326)
- Diogo O. Souza (ORCID: https://orcid.org/0000-0002-4322-0404)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Marie-Christine Guiot
- Antonio Aliaga (ORCID: https://orcid.org/0009-0006-9792-7815)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s13550-025-01216-8
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Alzheimer's Association
- Fondation Brain Canada
- Consortium canadien en neurodégénérescence associée au vieillissement
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé