Causal Relationships among Sedentary Behavior, Physical Activity, and Epilepsy: A Mendelian Randomization Analysis

This study aimed to investigate the causal relationship between sedentary behavior, physical activity, and epilepsy using two-sample Mendelian randomization. Genome-wide data were utilized for an association analysis, with sedentary behavior and physical activity as exposure factors and epilepsy as the outcome variable. MR-Egger, weighted median, and random-effects IVW methods were employed for the two-sample Mendelian randomization analyses, accompanied by heterogeneity tests, horizontal multivariate analyses, and sensitivity analyses. The results of MR-Egger regression, weighted median method, and random effect IVW method were 1.006 (0.994 - 1.018), 1.000 (0.996 - 1.004), and 1.001 (0.999 - 1.004), respectively, indicating that sedentary behavior and physical activity are risk factors for epilepsy development, and there is a positive association between them. In conclusion, there is a causal relationship between sedentary behavior, physical activity, and the risk of epilepsy.