Mutation analysis of Mycoplasma pneumoniae A2063G and A2064G in children infected with Mycoplasma pneumoniae in Tai'an area

Mycoplasma pneumoniae infection is a self-limiting disease, but if the infection is not treated in time, it can easily develop into severe pneumonia, bronchitis, asthma and community-acquired pneumonia, which seriously affects the health of the infected person. Macrolide antibiotics are the first choice for the treatment of Mycoplasma pneumoniae infection, and macrolide-resistant strains of Mycoplasma pneumoniae have been isolated in clinical practice. Patients infected with drug-resistant strains of Mycoplasma pneumoniae had significantly longer fever duration, hospitalisation time and fever duration after drug administration than sensitive strains. The aim of this study was to analyse the mutation of A2063G and A2064G drug-resistant gene loci in children with Mycoplasma pneumoniae infections admitted to Tai'an Maternal and Child Healthcare Hospital in the past two years, and to explore the epidemiological characteristics of these strains, so as to provide a basis for the prevention and treatment of Mycoplasma pneumoniae in children.