Analysis of Antibiotic Use in Premature Infants with Gestational Age less than 34 Weeks

This paper analyzes the use of antibiotics and recent clinical outcomes in premature infants with gestational age<34 weeks. This paper collects clinical data of 129 premature infants with gestational age<34 weeks admitted to the neonatal intensive care unit (NICU) of Texas City Hospital from January 1, 2017 to December 31, 2023. The research results found that there were a total of 129 premature infants with gestational age<34 weeks. The antibiotic use rate of premature infants with gestational age<34 weeks was 80.6%, and the median antibiotic use rate (AUR) per 100 days of hospital stay was 44. The incidence of infectious pneumonia in premature infants with gestational age less than 34 weeks is 59.7%, the incidence of bronchopulmonary dysplasia (BPD) is 7.8%, the incidence of neonatal pulmonary hemorrhage is 3.1%, the incidence of intraventricular hemorrhage (IVH) is 2.3%, the incidence of necrotizing enterocolitis (NEC) is 0.8%, the incidence of early onset sepsis (EOS) is 6.2%, the incidence of late onset sepsis (LOS) is 1.6%, and the mortality rate is 1.6%. The study suggests that premature infants with gestational age<34 weeks in our NICU have a longer duration of antibiotic use and a higher rate of antibiotic use, and further measures need to be taken to reduce the AUR of premature infants.