Layer-specific molecular signatures of colon anastomotic healing and leakage in mice
Mucosa/submucosa and muscularis externa are mostly in synchronization during the inflammation, proliferation, and extracellular remodeling stages during CAH. Transcriptional profiles within the anastomotic mucosa/submucosa differ between CAH and CAL in genes related to extracellular modelling and wound healing, indicating that genes of these pathways may contribute to CAL.
Authors
- Wouter J. de Jonge (ORCID: https://orcid.org/0000-0002-3241-1547)
- Bianca Schneiker
- Patrik Efferz
- Hilal Sengül (ORCID: https://orcid.org/0000-0002-8898-4723)
- Sven Wehner (ORCID: https://orcid.org/0000-0002-8632-7631)
- Andrew Y. F. Li Yim (ORCID: https://orcid.org/0000-0002-0754-0953)
- Patrick Leven (ORCID: https://orcid.org/0000-0002-6768-2523)
- Mariola Lysson
- Vasiliki Bantavi
- Laura Gloeck
Institutions
- University Hospital Bonn (DE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s10020-025-01167-9
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn
- HORIZON EUROPE Marie Sklodowska-Curie Actions